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LMK-235

a selective inhibitor of class IIA HDAC4/5

Also Known As:

Benzamide, N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethyl-; N-((6-(Hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Cheng, Bingqing: 2 articles (08/2018 - 01/2018)
2.	Fang, Qin: 2 articles (08/2018 - 01/2018)
3.	Lu, Tingting: 2 articles (08/2018 - 01/2018)
4.	Ma, Dan: 2 articles (08/2018 - 01/2018)
5.	Tang, Sishi: 2 articles (08/2018 - 01/2018)
6.	Wang, Jishi: 2 articles (08/2018 - 01/2018)
7.	Emerson, Robert E: 1 article (07/2021)
8.	Fan, Qipeng: 1 article (07/2021)
9.	Li, Lihong: 1 article (07/2021)
10.	Wang, Tian-Li: 1 article (07/2021)

Related Diseases

1.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/01/2018 - "In this study, we investigated the up-regulation of BCLAF1 through NF-κB signaling pathways in LMK-235, mediating the apoptosis of two diffuse large B-cell lymphoma cell lines, OCI-LY10 and OCI-LY3. "
2.	Carcinogenesis 07/29/2021 - "HDAC4 knockdown (KD) and LMK-235 inhibited spheroid formation in vitro and tumorigenesis in vivo, with hypoxia inducible factor-1 alpha (HIF1α) and endothelial growth factor A (VEGFA) as functional downstream mediators of HDAC4. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/15/2018 - "Up-regulation of HO-1 promotes resistance of B-cell acute lymphocytic leukemia cells to HDAC4/5 inhibitor LMK-235 via the Smad7 pathway."
4.	Sepsis (Septicemia) 01/01/2021 - "Ghrelin and E2F1 expression were increased by the treatment with HDAC5 inhibitor LMK-235, which inhibited the NF-κB pathway to improve intestinal dysfunction in the sepsis model. "
5.	Neuroendocrine Tumors (Neuroendocrine Tumor) 10/12/2018 - "Pharmacological Inhibition of Class IIA HDACs by LMK-235 in Pancreatic Neuroendocrine Tumor Cells."

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