GSK2193874

a transient receptor potential vanilloid 4 (TRPV4) inhibitor

Also Known As:

7-bromo-N-(1-phenylcyclopropyl)-3-((4-piperidin-1-ylpiperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenyl)quinoline-4-carboxamide

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - GSK2193874: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - GSK2193874: 7

Experts

1.	DU, Yi-Mei: 1 article (04/2022)
2.	Liao, Jie: 1 article (04/2022)
3.	Lu, Kai: 1 article (04/2022)
4.	Lu, Yang: 1 article (04/2022)
5.	Wu, Yu-Wei: 1 article (04/2022)
6.	Yang, Shuai-Tao: 1 article (04/2022)
7.	Fang, Xiang-Zhi: 1 article (11/2019)
8.	Li, Min: 1 article (11/2019)
9.	Liu, Xiao-Tian: 1 article (11/2019)
10.	Ma, Xiao-Dong: 1 article (11/2019)

Related Diseases

1.	Lung Injury 11/01/2019 - "In our study, we observe that blockade of TRPV4 using GSK2193874 or HC-067047 greatly improve the pneumonedema, the lung pathologic changes, the up-regulation of proinflammatory cytokines and the neutrophil infiltration in LPS-induced lung injury. "
2.	Heat Stroke (Heatstroke) 05/30/2018 - "Timely GSK2193874 administration may be useful to reduce heatstroke-induced injury. " 05/30/2018 - "But GSK2193874 treatment before heat stress did not improve the symptoms of heatstroke mice. " 05/30/2018 - "GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice." 05/30/2018 - "The results in murine models of heatstroke verified that GSK2193874, as a selected TRPV4 inhibitor, was injected at heatstroke onset, and then reduced the reduction of core temperature, the death rate, wet/dry ratio of the lung, levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, coagulation indicators, the degree of organ injury, and caspase-3/7 activity (P<0.05). "
3.	Pulmonary Edema 11/07/2012 - "Furthermore, in both acute and chronic HF models, GSK2193874 pretreatment inhibited the formation of pulmonary edema and enhanced arterial oxygenation. " 11/07/2012 - "Finally, GSK2193874 treatment resolved pulmonary edema already established by myocardial infarction in mice. "
4.	Pneumonia (Pneumonitis) 01/01/2023 - "In vivo mice data revealed that cold exposure compromised the airway epithelial barrier function, decreased occludin expression, and exacerbated lung inflammation, which was attenuated by the GSK2193874 or C4-ceramide injection. "
5.	Pericarditis 04/25/2022 - "Previously, we found that the expression and function of transient receptor potential vanilloid subtype 4 (TRPV4) are upregulated in a sterile pericarditis (SP) rat model of AF, and oral administration of TRPV4 inhibitor GSK2193874 alleviates AF in this animal model. "

Related Drugs and Biologics

1.	Cytokines
2.	HC-067047
3.	Occludin
4.	Caspase 3 (Caspase-3)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Interleukins
7.	GSK2798745
8.	N-butanoylsphingosine

Related Therapies and Procedures

1.	Oral Administration