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MB442

nicotinic antagonist effective against organophosophorous nerve agent poisoning in mice

Also Known As:

1,1'-(pentane-1,5-diyl)bispyridinium diiodide; MB442 compound

Networked: 2 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridinium Compounds: 5
      - MB442: 2

Experts

1.	Bird, Mike: 2 articles (04/2018 - 01/2018)
2.	Green, A Christopher: 2 articles (04/2018 - 01/2018)
3.	Kassa, Jiri: 2 articles (04/2018 - 01/2018)
4.	Tattersall, John E H: 2 articles (04/2018 - 01/2018)
5.	Timperley, Christopher M: 2 articles (04/2018 - 01/2018)
6.	Williams, Rebecca L: 2 articles (04/2018 - 01/2018)

Related Diseases

1.

04/01/2018 - "Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice."
04/01/2018 - "The influence of three newly developed bispyridinium antinicotinic compounds (the non-oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studied in mice. "
01/01/2018 - "The effect of three newly developed bispyridinium non-oxime compounds (MB408, MB442, and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with the oxime HI-6 or obidoxime) of acute poisoning by two nerve agents (sarin and cyclosarin) in mice was studied. "

Related Drugs and Biologics

1.	Oximes
2.	Atropine
3.	Nerve Agents
4.	MB444
5.	MB408
6.	Soman
7.	Sarin
8.	Obidoxime Chloride (Obidoxime)
9.	cyclohexyl methylphosphonofluoridate (cyclosarin)
10.	asoxime chloride (H16)