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LXM-15

spirocyclopiperazinium compound; has anti-inflammatory properties

Also Known As:

8-(m-nitrophenyl)-5,8-diazaspiro(4.5)decane bromide; LXM-15 compound

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - LXM-15: 3
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - LXM-15: 3

Experts

1.	Sun, Qi: 2 articles (06/2020 - 04/2018)
2.	Ye, Jia: 2 articles (06/2020 - 04/2018)
3.	Jiang, Yi Min: 1 article (06/2020)
4.	Li, Ning: 1 article (06/2020)
5.	Li, Run Tao: 1 article (06/2020)
6.	Liu, Qin: 1 article (06/2020)
7.	Jiang, Yimin: 1 article (04/2018)
8.	Li, Runtao: 1 article (04/2018)
9.	Liang, Yingying: 1 article (04/2018)
10.	Yang, Hua: 1 article (04/2018)

Related Diseases

1.	Pain (Aches) 04/01/2018 - "The aim of this study was to investigate the analgesic effect of the spirocyclopiperazinium salt compound LXM-15 by intragastric administration in thermal and chemical pain models and further to elucidate the possible molecular mechanisms. "
2.	Rheumatoid Arthritis 06/01/2020 - "In this study, we aimed to evaluate the effects of the spirocyclopiperazinium salt compound LXM-15 on rheumatoid arthritis induced by complete Freund's adjuvant (CFA) in rats and investigate the underlying mechanism. "
3.	Hyperalgesia 09/05/2023 - "Mechanical allodynia and thermal hyperalgesia tests were used to evaluate the effects of LXM-15 in SNL rats. " 06/01/2020 - "The results showed that LXM-15 significantly inhibited the paw edema and ankle swelling, and alleviated the mechanical allodynia and thermal hyperalgesia responses in the CFA rats. " 09/05/2023 - "Administration of LXM-15 (1, 0.5, 0.25 mg/kg, i.g.) dose-dependently attenuated mechanical allodynia and thermal hyperalgesia in rats subjected to SNL (p < 0.01, p < 0.05), and the effects were completely blocked by peripheral α7 nicotinic or M4 muscarinic receptor antagonist (p > 0.05). "
4.	Ganglion Cysts (Ganglion) 06/01/2020 - "Western blot analyses showed that LXM-15 significantly reduced the upregulation of phospho-JAK2, phospho-STAT3, phospho-IκBα, and phospho-NF-κBp65, and the overexpression of BDNF in the dorsal root ganglions. " 06/01/2020 - "RT-PCR analysis showed that the mRNA expression levels of c-fos and BDNF were reduced in the dorsal root ganglions by LXM-15 treatment. "
5.	Edema (Dropsy) 06/01/2020 - "The results showed that LXM-15 significantly inhibited the paw edema and ankle swelling, and alleviated the mechanical allodynia and thermal hyperalgesia responses in the CFA rats. "

Related Drugs and Biologics

1.	Salts
2.	Freund's Adjuvant
3.	Analgesics (Analgesic Drugs)
4.	Muscarinic M4 Receptor
5.	Brain-Derived Neurotrophic Factor (BDNF)
6.	Messenger RNA (mRNA)