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ORM-10962

a selective inhibitor of the Na+-Ca2+ exchanger (NCX) in cardiac myocytes

Also Known As:

2-(4-hydroxypiperidin-1-yl)-N-(6-((2-phenylchroman-6-yl)oxy)yridine-3-yl)acetamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Acsai, Károly: 1 article (01/2016)
2.	Baczkó, István: 1 article (01/2016)
3.	Corici, Claudia: 1 article (01/2016)
4.	Déri, Szilvia: 1 article (01/2016)
5.	Farkas-Morvay, Nikolett: 1 article (01/2016)
6.	Geramipour, Amir: 1 article (01/2016)
7.	Hornyik, Tibor: 1 article (01/2016)
8.	Horváth, András: 1 article (01/2016)
9.	Horváth, Balázs: 1 article (01/2016)
10.	Jost, Norbert: 1 article (01/2016)

Related Diseases

1.	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/01/2016 - "Pre-treatment with 0.3 mg/kg ORM-10962 (i.v.) 10 min before starting ouabain infusion significantly delayed the development and recurrence of ventricular extrasystoles (by about 50%) or ventricular tachycardia (by about 30%) in anesthetized guinea pigs. "
2.	Ventricular Tachycardia 01/01/2016 - "Pre-treatment with 0.3 mg/kg ORM-10962 (i.v.) 10 min before starting ouabain infusion significantly delayed the development and recurrence of ventricular extrasystoles (by about 50%) or ventricular tachycardia (by about 30%) in anesthetized guinea pigs. "
3.	Ischemia 01/01/2016 - "Antiarrhythmic effects of ORM-10962 were studied in anesthetized ouabain (10 μg/kg/min i.v.) pretreated guinea pigs and in ischemia-reperfusion models (I/R) of anesthetized coronary artery occluded rats and Langendorff perfused guinea pigs hearts. "

Related Drugs and Biologics

1.	Ouabain (G Strophanthin)