oxyfadichalcone C

isolated from Oxytropis falcate; has anti-proliferative and anti-metastatic effects on melanoma cells in vitro

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasm Metastasis (Metastasis) 08/01/2018 - "Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways." 08/01/2018 - "Such effects were associated with upregulation of p27, reduction of cyclin D1, p-pRb, p-Integrin β1, as well as the proteolytic activity of metalloproteinase (MMP)-2/9. Meanwhile, key molecules of PI3K/Akt and MAPK/ERK pathways were downregulated, which might be involved in the inhibition against proliferation and metastasis of A375 cells by Oxyfadichalcone C. "
2.	Melanoma (Melanoma, Malignant) 08/01/2018 - "Our findings suggest that Oxyfadichalcone C has the potential to be developed as a promising drug candidate for the treatment of melanoma." 08/01/2018 - "We recently isolated Oxyfadichalcone C from Oxytropis falcate and investigated the anti-proliferative and anti-metastatic activity on human melanoma A375 cells in vitro. " 08/01/2018 - "Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways."

1.	Metalloproteases (Metalloproteinases)
2.	Matrix Metalloproteinases (MMPs)
3.	Cyclin D1
4.	Integrins