gladiolin

macrolide antibiotic isolated from Burkholderia gladioli and structurally related to etnangien; it is an inhibitor of RNA polymerase and has potent activity against Mycobacterium tuberculosis

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        gladiolin: 1
- Lactones: 1549
  - Macrolides: 4391
    - gladiolin: 1
  - Polyketides: 231
    - Macrolides: 4391
      - gladiolin: 1
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Polyketides: 231
    - Macrolides: 4391
      - gladiolin: 1

Experts

1.	Bull, Matthew J: 1 article (01/2017)
2.	Challis, Gregory L: 1 article (01/2017)
3.	Cole, Stewart T: 1 article (01/2017)
4.	Coupland, Paul: 1 article (01/2017)
5.	Dunn, Matthew: 1 article (01/2017)
6.	Harris, Simon R: 1 article (01/2017)
7.	Hartkoorn, Ruben C: 1 article (01/2017)
8.	Jenner, Matthew: 1 article (01/2017)
9.	Jones, Cerith: 1 article (01/2017)
10.	Mahenthiralingam, Eshwar: 1 article (01/2017)

Related Diseases

1.	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/01/2017 - "Overall, these data suggest that gladiolin may represent a useful starting point for the development of novel drugs to tackle multidrug-resistant tuberculosis. "
2.	Cystic Fibrosis (Mucoviscidosis) 01/01/2017 - "An antimicrobial activity screen of Burkholderia gladioli BCC0238, a clinical isolate from a cystic fibrosis patient, led to the discovery of gladiolin, a novel macrolide antibiotic with potent activity against Mycobacterium tuberculosis H37Rv. "

Related Drugs and Biologics

1.	Macrolides
2.	Anti-Bacterial Agents (Antibiotics)