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Sul-121

prevents LPS-induced airway neutrophilia and hyperresponsiveness in guinea pig model

Also Known As:

6-hydroxy-2,5,7,8- tetramethylchroman-2-yl (piperazin-1-yl) methanone

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromans: 3
        Sul-121: 2
  - Piperazines: 26
    - Sul-121: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromans: 3
        Sul-121: 2

Experts

1.	Bidadkosh, A: 1 article (11/2017)
2.	Buikema, H: 1 article (11/2017)
3.	Deelman, L E: 1 article (11/2017)
4.	Girgis, R A T: 1 article (11/2017)
5.	Henning, R H: 1 article (11/2017)
6.	Koster, R A: 1 article (11/2017)
7.	Lambooy, S P H: 1 article (11/2017)
8.	Nakladal, D: 1 article (11/2017)
9.	Vogelaar, P: 1 article (11/2017)
10.	Wiedenmann, T J: 1 article (11/2017)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2016 - "Our data show that Sul-121 effectively inhibits airway inflammation and AHR in experimental COPD models, prospectively through inhibition of oxidative stress." 01/01/2016 - "Here, we explore the effects of Sul-121, a novel compound with anti-oxidative capacity, on hyperresponsiveness (AHR) and inflammation in experimental models of COPD. " 01/01/2016 - "The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease."
2.	Sclerosis 11/01/2017 - "Sul-121 prevented progression of albuminuria and attenuated kidney damage in db/db, as evidenced by lower glomerular fibronectin expression (~50%), decreased focal glomerular sclerosis score (~40%) and normalization of glomerular size and kidney weight. "
3.	Inflammation (Inflammations) 01/01/2016 - "Our data show that Sul-121 effectively inhibits airway inflammation and AHR in experimental COPD models, prospectively through inhibition of oxidative stress." 01/01/2016 - "Here, we explore the effects of Sul-121, a novel compound with anti-oxidative capacity, on hyperresponsiveness (AHR) and inflammation in experimental models of COPD. " 01/01/2016 - "The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease."
4.	Type 2 Diabetes Mellitus (MODY) 11/01/2017 - "The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice."
5.	Albuminuria 11/01/2017 - "Sul-121 prevented progression of albuminuria and attenuated kidney damage in db/db, as evidenced by lower glomerular fibronectin expression (~50%), decreased focal glomerular sclerosis score (~40%) and normalization of glomerular size and kidney weight. "

Related Drugs and Biologics

1.	Fibronectins (Fibronectin)