LG325

selective inhibitor of histone deacetylase (HDAC)-1; ameliorates neuropathic pain in a mouse model

Also Known As:

N1-hydroxy-N6-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)hexanediamide

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - LG325: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        LG325: 2

Experts

1.	Galeotti, Nicoletta: 2 articles (04/2018 - 01/2017)
2.	Sanna, Maria Domenica: 2 articles (04/2018 - 01/2017)
3.	Guandalini, Luca: 1 article (01/2017)
4.	Romanelli, Maria Novella: 1 article (01/2017)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2017 - "These data illustrate the antihyperalgesic efficacy of LG325 indicating that selectively targeting HDAC1 could have promising therapeutic potential for neuropathic pain management." 01/01/2017 - "The new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model." 01/01/2017 - "To obtain an innovative treatment for the management of neuropathic pain, we investigated the pharmacological effects produced by the new histone deacetylase (HDAC)-1 selective inhibitor, LG325, in a mouse model of trauma-induced peripheral mononeuropathy provoked by spared nerve injury (SNI). "
2.	Mononeuropathies (Mononeuritis Multiplex) 01/01/2017 - "To obtain an innovative treatment for the management of neuropathic pain, we investigated the pharmacological effects produced by the new histone deacetylase (HDAC)-1 selective inhibitor, LG325, in a mouse model of trauma-induced peripheral mononeuropathy provoked by spared nerve injury (SNI). "
3.	Wounds and Injuries (Trauma) 01/01/2017 - "To obtain an innovative treatment for the management of neuropathic pain, we investigated the pharmacological effects produced by the new histone deacetylase (HDAC)-1 selective inhibitor, LG325, in a mouse model of trauma-induced peripheral mononeuropathy provoked by spared nerve injury (SNI). "
4.	Pain (Aches) 04/15/2018 - "Administration of a selective HDAC1 inhibitor (LG325) in SNI-subjected mice significantly attenuated behavior related to injury-induced pain. "
5.	Hyperalgesia 01/01/2017 - "LG325 dose-dependently ameliorated the mechanical allodynia of SNI mice with a prolonged effect that was still significant 150min after administration. "

Related Drugs and Biologics

1.	Histone Deacetylases (Histone Deacetylase)