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JPI-289

a PARP-1 inhibitor with neuroprotective activity; structure in first source

Also Known As:

10-ethoxy-8-(morpholinomethyl)-1,2,3,4-tetrahydrobenzo(h)(1,6)naphthyridin-5(6H)-one

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - JPI-289: 3

Experts

1.	Noh, Min-Young: 3 articles (09/2018 - 06/2017)
2.	Kim, Hyun Young: 2 articles (09/2018 - 07/2018)
3.	Kim, Jeongmin: 2 articles (09/2018 - 06/2017)
4.	Kim, Seung Hyun: 2 articles (09/2018 - 07/2018)
5.	Kim, Young Seo: 2 articles (09/2018 - 07/2018)
6.	Kim, Youngchul: 2 articles (09/2018 - 06/2017)
7.	Park, Jiseon: 2 articles (09/2018 - 06/2017)
8.	Kim, Ji Young: 1 article (09/2018)
9.	Lee, Young-Jun: 1 article (09/2018)
10.	Lee, Su-Jung: 1 article (07/2018)

Related Diseases

1.	Ischemic Stroke 07/01/2018 - "Treg proportions are reduced in ischemic stroke patients and increased by treatment with high-dose PARP-1 inhibitor JPI-289. " 09/01/2018 - "The current study investigated the neuroprotective effect of a novel PARP-1 inhibitor, JPI-289, in an animal model of ischemic stroke. " 06/01/2017 - "The present findings suggest that the novel PARP-1 inhibitor, JPI-289, is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke."
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 09/01/2018 - "A transient middle cerebral artery occlusion (tMCAO, 2 h) model was used to determine the therapeutic effect and the most effective dose and time window of administration of JPI-289. "
3.	Infarction (Infarctions) 09/01/2018 - "JPI-289 also reduced infarct volume by 16% in the permanent MCAO model. " 09/01/2018 - "However, infarct volume and brain swelling were significantly reduced in the group treated with JPI-289 (2 h) at 24 h and 7 days after MCAO. "
4.	Brain Edema (Cerebral Edema) 09/01/2018 - "However, infarct volume and brain swelling were significantly reduced in the group treated with JPI-289 (2 h) at 24 h and 7 days after MCAO. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	Therapeutic Uses