ZelNate

has immunostimulatory activity; bacterial DNA rich in non-methylated CpG motifs that is incorporated into a cationic liposome

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Ilg, Thomas: 1 article (10/2017)

1.	Melanoma (Melanoma, Malignant) 10/01/2017 - "However, in the human monocyte cell line THP1 and in the mouse melanoma cell line B16, ZelNate activates strongly the stimulator of interferon genes (STING) pathway, which is known to lead predominantly to interferon response factor 3 (IRF3) activation. "
2.	Bites and Stings (Sting) 10/01/2017 - "Our in vitro observations suggest that ZelNate may act predominantly via the cGAS/STING/IRF3 pathway." 10/01/2017 - "Investigations on the molecular mode of action of the novel immunostimulator ZelNate: Activation of the cGAS-STING pathway in mammalian cells." 10/01/2017 - "However, in the human monocyte cell line THP1 and in the mouse melanoma cell line B16, ZelNate activates strongly the stimulator of interferon genes (STING) pathway, which is known to lead predominantly to interferon response factor 3 (IRF3) activation. " 10/01/2017 - "Further analysis in THP1 cells suggests that the ZelNate plasmid DNA activates STING via interaction with cyclic guanylate adenylate synthase (cGAS), but not via interferon induced gene 16 (IFI16). "