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GSK656

a leucyl-tRNA synthetase inhibitor with antitubercular activity; structure in first source

Also Known As:

3-(aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo(c)(1,2)oxaborol-1(3H)-ol; GSK3036656

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Mendoza-Losana, Alfonso: 2 articles (01/2019 - 10/2017)
2.	Bouz, Ghada: 1 article (01/2021)
3.	Zitko, Jan: 1 article (01/2021)
4.	Barros-Aguirre, David: 1 article (01/2019)
5.	Carlton, Alex: 1 article (01/2019)
6.	Cozens, Simon: 1 article (01/2019)
7.	Davies, Matt: 1 article (01/2019)
8.	Derimanov, Geo: 1 article (01/2019)
9.	Gaudion, Alison: 1 article (01/2019)
10.	Gresham, Stephanie: 1 article (01/2019)

Related Diseases

1.

Tuberculosis (Tuberculoses)

01/01/2021 - "The most promising aaRS inhibitor as an antimycobacterial compound is GSK656 (compound 8), the only aaRS inhibitor in clinical trials (Phase IIa) for systemic use against tuberculosis. "
01/01/2019 - "First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment."
10/12/2017 - "tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)."
10/12/2017 - "Further evaluation of these Mtb LeuRS inhibitors by in vivo pharmacokinetics (PK) and murine tuberculosis (TB) efficacy models led to the discovery of GSK3036656 (abbreviated as GSK656). "

Related Drugs and Biologics

1.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
2.	GSK656