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2- (((2- (tetradecyloxy)phenyl)amino)carbonyl)benzoic acid

a protein tyrosine phosphatase 1B inhibitor with antidiabetic activity; structure in first source

Also Known As:

CX08005

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - 2-(((2-(tetradecyloxy)phenyl)amino)carbonyl)benzoic acid: 2
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phthalic Acids: 1
      - 2-(((2-(tetradecyloxy)phenyl)amino)carbonyl)benzoic acid: 2

Experts

1.	Huang, Liwei: 1 article (01/2016)
2.	Li, Juan: 1 article (01/2016)
3.	Liang, Wei: 1 article (01/2016)
4.	Tian, Jinying: 1 article (01/2016)
5.	Wu, Song: 1 article (01/2016)
6.	Ye, Fei: 1 article (01/2016)
7.	Ye, Jianping: 1 article (01/2016)
8.	Zhang, Xiaolin: 1 article (01/2016)
9.	Zhong, Liangwei: 1 article (01/2016)

Related Diseases

1.	Glucose Intolerance 01/01/2016 - "In KKAy mice, CX08005 (50 mg·kg(-1) ·day(-1) ) improved glucose intolerance, GSIS, ISWB and hyperglycaemia. " 01/01/2016 - "In DIO mice, CX08005 ameliorated glucose intolerance dose-dependently (50-200 mg·kg(-1) ·day(-1) ) and decreased the HOMA-IR. "
2.	Obesity 01/11/2023 - "The present study aimed to investigate the effects of CX08005 on hepatic lipid accumulation and microcirculation dysfunction in both KKAy mice and diet-induced obesity (DIO) mice. "
3.	Non-alcoholic Fatty Liver Disease 01/11/2023 - "Taken together, CX08005 exhibited beneficial effects on hepatic lipid accumulation and microcirculation dysfunction associated with NAFLD, which was involved with modulating insulin sensitivity and leukocyte recruitment, as well as restoration of normal microcirculatory blood flow." 01/11/2023 - "CX08005, a Protein Tyrosine Phosphatase 1B Inhibitor, Attenuated Hepatic Lipid Accumulation and Microcirculation Dysfunction Associated with Nonalcoholic Fatty Liver Disease."
4.	Insulin Resistance 01/11/2023 - "Furthermore, we found that CX08005 treatment significantly enhanced insulin sensitivity, and decreased plasma TG and/or TC contents in KKAy and DIO mice, respectively. " 01/11/2023 - "CX08005, an inhibitor of PTP1B with the IC50 of 0.75 ± 0.07 μM, has been proven to directly enhance insulin sensitivity. " 01/11/2023 - "Taken together, CX08005 exhibited beneficial effects on hepatic lipid accumulation and microcirculation dysfunction associated with NAFLD, which was involved with modulating insulin sensitivity and leukocyte recruitment, as well as restoration of normal microcirculatory blood flow."

Related Drugs and Biologics

1.	Lipids
2.	Non-Receptor Type 1 Protein Tyrosine Phosphatase