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AZ3451

a protease-activated receptor 2 antagonist

Also Known As:

2-(6-bromobenzo(d)(1,3)dioxol-5-yl)-N-(4-cyanophenyl)-1-(1-cyclohexylethyl)-1Hbenzo(d)imidazole-5-carboxamide

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Benzodioxoles: 3
      - AZ3451: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - AZ3451: 4
    - Benzodioxoles: 3
      - AZ3451: 4

Experts

1.	Aramgam, Sree Latha: 1 article (12/2021)
2.	Lokhande, Kiran Bharat: 1 article (12/2021)
3.	Padmavathi, Pannuru: 1 article (12/2021)
4.	Pal, Meena: 1 article (12/2021)
5.	Pulakuntla, Swetha: 1 article (12/2021)
6.	Reddy, Vaddi Damodara: 1 article (12/2021)
7.	Sadasivam, Jayashree: 1 article (12/2021)
8.	Singh, Shri Abhiav: 1 article (12/2021)
9.	Swamy, Kakumani Venkateswara: 1 article (12/2021)
10.	Bai, Xiaopeng: 1 article (10/2021)

Related Diseases

1.	Osteoarthritis 12/16/2019 - "Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis."
2.	COVID-19 12/01/2021 - "The spike receptor binding protein (RBD) used as target region for our studies with FDA-approved drugs for repurposing, and identified few anti-SARS-CoV2 potential drugs (Silmitasertib, AC-55541, Merimepodib, XL413, AZ3451) based on their docking score and binding mode calculations expected to strongly bind to motifs of ACE2 receptor and may show impart relief in COVID-19 patients."
3.	Inflammation (Inflammations) 12/16/2019 - "We demonstrated AZ3451 could prevent the IL-1β-induced inflammation response, cartilage degradation and premature senescence in chondrocytes. " 12/16/2019 - "Here, we investigated the role of PAR2 antagonist AZ3451 in inflammation response, apoptosis, autophagy and cellular senescence during OA. " 10/18/2021 - "Protease-Activated Receptor 2 (PAR-2) Antagonist AZ3451 Mitigates Oxidized Low-Density Lipoprotein (Ox-LDL)-Induced Damage and Endothelial Inflammation."
4.	Hyperuricemia 01/01/2023 - "The PAR2 antagonist AZ3451 may be a promising therapeutic strategy for hyperuricemia-induced inflammatory responses."

Related Drugs and Biologics

1.	PAR-2 Receptor
2.	Carrier Proteins (Binding Protein)
3.	silmitasertib
4.	N- 3- (3- (3- methoxy- 4- oxazol- 5- ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester
5.	oxidized low density lipoprotein