UW-MD-72 compound

an acetylcholinesterase inhibitor and a histamine H3 receptor antagonist; structure in first source

Also Known As:

7-(3-(piperidin-1-yl)propoxy)-2,3-dihydropyrrolo(2,1-b)quinazolin-9(1H)-one; UW-MD-72

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - UW-MD-72 compound: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - Quinazolinones: 124
        UW-MD-72 compound: 1

Experts

1.	Darras, Fouad H: 1 article (10/2016)
2.	Decker, Michael: 1 article (10/2016)
3.	Khan, Nadia: 1 article (10/2016)
4.	Pockes, Steffen: 1 article (10/2016)
5.	Sadek, Bassem: 1 article (10/2016)

Related Diseases

1.	Memory Disorders (Memory Loss) 10/15/2016 - "In the current study, the effects of UW-MD-72 (1.25, 2.5, and 5mg/kg, i.p.) on memory deficits induced by the muscarinic cholinergic antagonist scopolamine (SCO) and the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (DIZ) were investigated in a step-through type passive avoidance paradigm in adult male rats applying donepezil (DOZ) and pitolisant (PIT) as reference drugs. "
2.	Cognitive Dysfunction 10/15/2016 - "These results demonstrate the ameliorative effects of UW-MD-72 in two in-vivo memory models and provide evidence for the potential of dual-acting AChEI and H3R antagonists to treat cognitive disorders."
3.	Amnesia (Dissociative Amnesia) 10/15/2016 - "Moreover, ameliorative effect of UW-MD-72 (1.25mg/kg, i.p.) in DIZ-induced amnesia was strongly reversed when rats were pretreated with a combination of ZOL (10mg/kg, i.p.) and SCO (1.0mg/kg, i.p.), indicating that these memory enhancing effects were, in addition to other neural circuits, observed through histaminergic H2R as well as muscarinic cholinergic neurotransmission. " 10/15/2016 - "Furthermore, the ameliorating activity of UW-MD-72 (1.25mg/kg, i.p.) in DIZ-induced amnesia was partly reversed when rats were pretreated with the centrally-acting H2R antagonist zolantidine (ZOL, 10mg/kg, i.p.), but not with the CNS penetrant H1R antagonist pyrilamine (PYR, 10mg/kg, i.p.). " 10/15/2016 - "The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats."

Related Drugs and Biologics

1.	Cholinergic Antagonists (Anticholinergics)
2.	Cholinergic Agents (Cholinergics)
3.	Dizocilpine Maleate (Dizocilpine)
4.	N-Methylaspartate (NMDA)
5.	Scopolamine (Hyoscine)
6.	Donepezil (Aricept)
7.	pitolisant
8.	Histamine H3 Receptors (Histamine H3 Receptor)
9.	Pyrilamine (Mepyramine)
10.	zolantidine