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12-hydroxy-8,10,14-eicosatrienoic acid

a thrombosis inhibitor

Also Known As:

12-HETrE

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - 8,11,14-Eicosatrienoic Acid: 104
        12-hydroxy-8,10,14-eicosatrienoic acid: 7

Experts

1.	Dunn, M W: 2 articles (02/2001 - 07/2000)
2.	Mieyal, P A: 2 articles (02/2001 - 07/2000)
3.	Schwartzman, M L: 2 articles (02/2001 - 07/2000)
4.	Adili, Reheman: 1 article (06/2017)
5.	Ebrahem, Meral: 1 article (06/2017)
6.	Freedman, J Cody: 1 article (06/2017)
7.	Holinstat, Michael: 1 article (06/2017)
8.	Holman, Theodore R: 1 article (06/2017)
9.	Isingizwe, Zitha R: 1 article (06/2017)
10.	Tourdot, Benjamin E: 1 article (06/2017)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2001 - "The increased levels of 12-HETrE associated with ocular surface inflammation suggest that this eicosanoid may contribute to inflammation of the ocular surface in humans." 04/01/1995 - "The relationship between 12-HETE and 12-HETrE synthesis and the degree of anterior surface inflammation implicate these eicosanoids, among others, as mediators of the inflammatory response to hydrogel contact lens wear in the closed eye."
2.	Hypoxia (Hypoxemia) 07/01/2000 - "Culture in hypoxia further increased intracellular 12-HETE threefold but had no additional effect on 12-HETrE. " 06/01/1999 - "Antibodies against CYP4B1, but not against CYP4A1, inhibited hypoxia-, clofibrate-, and phenobarbital-induced 12-HETE and 12-HETrE synthesis. "
3.	Corneal Neovascularization 11/01/2007 - "We used siRNA duplexes targeting CYP4B1 to substantiate the link between CYP4B1 expression, 12-HETrE production and angiogenesis in a model of suture-induced corneal neovascularization. "
4.	Corneal Edema 07/01/2000 - "Additionally, the findings suggest that 12-HETE produced by the corneal epithelium acts intracellularly to promote corneal edema, whereas 12-HETrE acts in a paracrine manner to initiate an inflammatory cascade that can elicit neutrophil chemotaxis and neovascularization of the cornea."
5.	Thrombosis (Thrombus) 06/27/2017 - "12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor."

Related Drugs and Biologics

1.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
2.	Eicosanoids
3.	cytochrome P-450 CYP4B1 (CYP4B1)
4.	Epoprostenol Receptors
5.	Small Interfering RNA (siRNA)
6.	Hydrogels
7.	Phenobarbital (Luminal)
8.	Clofibrate
9.	Antibodies
10.	Alkalies

Related Therapies and Procedures

1.	Sutures (Suture)
2.	Contact Lenses