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BL-038

antineoplastic; structure in first source

Also Known As:

(2-amino-3-(2,6-dichlorophenyl)-6-(4-methoxyphenyl)benzofuran-4-yl acetate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - BL-038: 1

Experts

1.	Chang, Chih-Shiang: 1 article (09/2016)
2.	Chen, Chien-Yu: 1 article (09/2016)
3.	Chen, Hsien-Te: 1 article (09/2016)
4.	Liu, Ju-Fang: 1 article (09/2016)
5.	Tang, Chih-Hsin: 1 article (09/2016)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 09/07/2016 - "BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway."
2.	B-Cell Lymphoma (Lymphoma, B Cell) 09/07/2016 - "Furthermore, BL-038 decreased mitochondrial membrane potential (MMP) and changed mitochondrial-related apoptosis, by downregulating the anti-apoptotic activity members (Bcl-2, Bcl-xL) and upregulating pro-apoptotic members (Bax, Bak) of the B-cell lymphoma 2 (Bcl-2) family of proteins, key regulators of the apoptotic machinery in cells. "
3.	Chondrosarcoma 09/07/2016 - "BL-038 caused cell apoptosis in two human chondrosarcoma cell lines, JJ012 and SW1353, but not in primary chondrocytes. " 09/07/2016 - "Our results show that the benzofuran derivative BL-038 induces apoptosis in chondrosarcoma cells. " 09/07/2016 - "Treatment of chondrosarcoma with BL-038 also induced reactive oxygen species (ROS) production. " 09/07/2016 - "The novel benzofuran derivative, BL-038 (2-amino-3-(2,6-dichlorophenyl)-6-(4-methoxyphenyl)benzofuran-4-yl acetate), has been evaluated for its anticancer effects in human chondrosarcoma cells. " 09/07/2016 - "BL-038, a Benzofuran Derivative, Induces Cell Apoptosis in Human Chondrosarcoma Cells through Reactive Oxygen Species/Mitochondrial Dysfunction and the Caspases Dependent Pathway."

Related Drugs and Biologics

1.	Caspase 9
2.	Caspase 3 (Caspase-3)
3.	Cytochromes c (Cytochrome c)
4.	Matrix Metalloproteinases (MMPs)
5.	Caspases
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Proteins (Proteins, Gene)
8.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
9.	benzofuran