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LM609 monoclonal antibody

anti-integrin alphaVbeta3 antibody, clone LM609

Also Known As:

LM609 MAb; MAb LM609

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        LM609 monoclonal antibody: 3
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        LM609 monoclonal antibody: 3
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        LM609 monoclonal antibody: 3

Experts

1.	Li, Ya-li: 1 article (06/2005)
2.	Zhao, Jun: 1 article (06/2005)
3.	Zong, Li-li: 1 article (06/2005)
4.	Gardiner, Brooke B: 1 article (01/2002)
5.	Herlyn, Meenhard: 1 article (01/2002)
6.	Meier, Freidegund: 1 article (01/2002)
7.	Satyamoorthy, Kapaeth: 1 article (01/2002)
8.	Smit, Darren J: 1 article (01/2002)
9.	Sturm, Richard A: 1 article (01/2002)
10.	Vaidya, Bhavesh: 1 article (01/2002)

Related Diseases

1.	Osteoarthritis 03/01/2000 - "In contrast, alpha v beta 3 complex-specific function-blocking mAb (LM609), which acts as an agonist similar to OPN, attenuates the production of IL-1 beta, NO, and PGE2 (triggered by alpha 5 beta 1, IL-1 beta, IL-18, or IL-1 beta, TNF-alpha, plus LPS) in a dominant negative fashion by osteoarthritis-affected cartilage and activated bovine chondrocytes. "
2.	Melanoma (Melanoma, Malignant) 01/01/2002 - "Osteonectin expression was not blocked when melanoma cells were cultured with anti-alpha(v)beta(3) LM609 mAb, mitogen-activated protein kinase, or protein kinase C inhibitors, indicating that other signaling pathway(s) operate through alpha(v)beta(3) integrin during conversion from RGP to VGP."
3.	Endometriosis 06/01/2005 - "To explore the potential use of integrin av beta3 (Lm609) monoclonal antibody against ectopic lesion and microvessel angiogenesis of human endometriosis xenografts in SCID mice. "

Related Drugs and Biologics

1.	Interleukin-1beta (Interleukin 1 beta)
2.	Integrin beta3 (GPIIIa)
3.	Mitogen-Activated Protein Kinases
4.	Integrins
5.	Osteonectin
6.	Dinoprostone (PGE2)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Protein Kinase C