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LX2343

a cognitive enhancer with anti-amyloid activity; structure in first source

Also Known As:

N-(1,3-benzodioxol-5-yl)-2-(5-chloro-2-methoxy(phenylsulfonyl)anilino)acetamide

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Shen, Xu: 3 articles (02/2018 - 09/2016)
2.	Guo, Xiao-Dan: 2 articles (08/2017 - 09/2016)
3.	Hu, Li-Hong: 2 articles (08/2017 - 09/2016)
4.	Rukachaisirikul, Vatcharin: 2 articles (08/2017 - 09/2016)
5.	Sun, Guang-Long: 2 articles (08/2017 - 09/2016)
6.	Xu, Xin: 2 articles (08/2017 - 09/2016)
7.	Zhou, Ting-Ting: 2 articles (08/2017 - 09/2016)
8.	Zhu, Zhi-Yuan: 2 articles (08/2017 - 09/2016)
9.	Guo, Xiaodan: 1 article (02/2018)
10.	Hu, Lihong: 1 article (02/2018)

Related Diseases

1.	Cognitive Dysfunction 09/01/2016 - "LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Aβ production inhibition and clearance promotion, which highlights the potential of LX2343 in the treatment of AD." 08/01/2017 - "LX2343 ameliorates the cognitive dysfunction in the AD model rats by suppressing OS-induced neuronal apoptosis and tauopathy, thus highlighting the potential of LX2343 for the treatment of AD." 08/01/2017 - "LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy." 08/01/2017 - "Here, we demonstrated the capability of the small molecule N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343) to ameliorate the cognitive dysfunction of AD model rats by inhibiting OS-induced neuronal apoptosis and tauopathy. "
2.	Tauopathies 08/01/2017 - "LX2343 ameliorates the cognitive dysfunction in the AD model rats by suppressing OS-induced neuronal apoptosis and tauopathy, thus highlighting the potential of LX2343 for the treatment of AD." 08/01/2017 - "LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy." 08/01/2017 - "Here, we demonstrated the capability of the small molecule N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343) to ameliorate the cognitive dysfunction of AD model rats by inhibiting OS-induced neuronal apoptosis and tauopathy. "
3.	Amyloid Plaque 09/01/2016 - "After LX2343 administration, cognitive ability of the mice was evaluated using Morris water maze test, and senile plaques in the brains were detected using Thioflavine S staining. "
4.	Alzheimer Disease (Alzheimer's Disease) 02/10/2018 - "A series of LX2343 derivatives were designed, synthesized and evaluated as neuroprotective agents for Alzheimer's disease (AD) in vitro. " 02/10/2018 - "Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease."

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	acetamide
3.	thioflavin T