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Vasculotide

a synthetic polyethylene glycol-clustered Tie2 agonist peptide

Also Known As:

VT peptide

Networked: 14 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Peptide Fragments: 373
    - Vasculotide: 14

Experts

1.	Van Slyke, Paul: 11 articles (05/2021 - 06/2009)
2.	Dumont, Daniel J: 6 articles (01/2021 - 01/2011)
3.	van Leeuwen, Anoek L I: 2 articles (05/2021 - 01/2018)
4.	van Meurs, Matijs: 2 articles (05/2021 - 01/2018)
5.	van den Brom, Charissa E: 2 articles (05/2021 - 01/2018)
6.	Chopp, Michael: 2 articles (01/2021 - 12/2018)
7.	Landschoot-Ward, Julie: 2 articles (01/2021 - 12/2018)
8.	Liang, Linlin: 2 articles (01/2021 - 12/2018)
9.	Ning, Ruizhuo: 2 articles (01/2021 - 12/2018)
10.	Venkat, Poornima: 2 articles (01/2021 - 12/2018)

Related Diseases

1.	Edema (Dropsy) 05/17/2021 - "Vasculotide did not improve renal perfusion (p > 0.9 at all time points) or reduce renal injury (NGAL p = 0.26, KIM-1 p = 0.78, creatinine p > 0.9, renal edema p = 0.08), but temporarily improved cremaster perfusion at 3 h following start of fluid resuscitation compared to untreated rats (resuscitation + 3 h: 11 ± 3 vs 8 ± 3 perfused vessels, p < 0.05). " 06/05/2015 - "Administration of the drug decreased lung edema, arterial hypoxemia and lung endothelial apoptosis; importantly, Vasculotide is inexpensive to produce, is chemically stable and is unrelated to any Tie2 ligands. "
2.	Sepsis (Septicemia) 01/01/2011 - "The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis." 01/01/2011 - "Here we evaluate the efficacy of a novel polyethylene glycol (PEG)-clustered Tie2 agonist peptide, Vasculotide (VT), to protect against vascular leakage and mortality in a murine model of polymicrobial abdominal sepsis. "
3.	Atopic Dermatitis (Atopic Eczema) 05/28/2016 - "Vasculotide, an Angiopoietin-1 mimetic, ameliorates several features of experimental atopic dermatitis-like disease."
4.	Inflammation (Inflammations) 12/01/2018 - "In this study, we test the hypothesis that vasculotide treatment induces neuroprotection and decreases inflammation after stroke in type 1 diabetic (T1DM) rats. " 08/26/2014 - "Vasculotide alleviated irradiation-induced inflammation in the form of reduced levels of oxygenated hemoglobin, myeloperoxidase bioluminescence and chemokine MIP-2. "
5.	Stroke (Strokes) 12/01/2018 - "In this study, we test the hypothesis that vasculotide treatment induces neuroprotection and decreases inflammation after stroke in type 1 diabetic (T1DM) rats. " 12/01/2018 - "Decreased neuroinflammation and reduced BBB leakage may contribute, at least in part, to vasculotide-induced neuroprotective effects after stroke in T1DM rats."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Angiopoietin-1
3.	Polyethylene Glycols (Polyethylene Glycol)
4.	Creatinine
5.	Neuroprotective Agents
6.	Chemokine CXCL2
7.	Phosphates (Orthophosphate)
8.	Peroxidase (Myeloperoxidase)
9.	Ligands
10.	Hemoglobins (Hemoglobin)

Related Therapies and Procedures

1.	Resuscitation
2.	Microbubbles
3.	Therapeutics