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1- (1- (3- (methylsulfonyl)phenyl)- 7- propoxyindolizin- 3- yl)ethanone

a probe for BAZ2 bromodomains; structure in first source

Also Known As:

GSK2801

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indolizines: 3
      - 1-(1-(3-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone: 4
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - 1-(1-(3-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone: 4

Experts

1.	Koestler, Devin C: 1 article (06/2022)
2.	Ly, Thuc: 1 article (06/2022)
3.	Pei, Dong: 1 article (06/2022)
4.	Sardiu, Mihaela E: 1 article (06/2022)
5.	Thompson, Jeffery A: 1 article (06/2022)
6.	Welch, Danny R: 1 article (06/2022)
7.	Yellapu, Nanda Kumar: 1 article (06/2022)
8.	Gopal, Purva: 1 article (01/2022)
9.	Jia, Yuemeng: 1 article (01/2022)
10.	Li, Lin: 1 article (01/2022)

Related Diseases

1.	Triple Negative Breast Neoplasms 06/08/2022 - "Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer." 01/01/2019 - "GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer."
2.	Anaplastic Thyroid Carcinoma 03/22/2023 - "GSK2801 Reverses Paclitaxel Resistance in Anaplastic Thyroid Cancer Cell Lines through MYCN Downregulation."
3.	Wounds and Injuries (Trauma) 01/01/2022 - "Distinct BAZ2-specific bromodomain inhibitors, GSK2801 and BAZ2-ICR, resulted in accelerated liver healing after diverse injuries. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/08/2022 - "Functional enrichment analyses identified several metabolic pathways (i.e., systemic lupus erythematosus, PI3K-Akt, TNF, JAK-STAT, IL-17, MAPK, Rap1 and signaling pathways) enriched with upregulated and downregulated genes when combined JQ1 and GSK2801 treatment was administered. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)