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4-oxo-5,7,10,13,16,19-docosahexaenoic acid

a metabolite of docosahexaenoic acid with antineoplastic activity; structure in first source

Also Known As:

4-OXO-DHA; 4-oxodocosahexaenoic acid

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793

Experts

1.	Manni, Andrea: 3 articles (12/2021 - 02/2015)
2.	Amin, Shantu: 2 articles (11/2021 - 02/2015)
3.	El-Bayoumy, Karam: 2 articles (11/2021 - 02/2015)
4.	Gowda, Krishne: 2 articles (11/2021 - 02/2015)
5.	El Bayoumy, Karam: 1 article (12/2021)
6.	Fitzgerald, Vanessa K: 1 article (12/2021)
7.	McGinley, John N: 1 article (12/2021)
8.	Neil, Elizabeth S: 1 article (12/2021)
9.	Thompson, Henry J: 1 article (12/2021)
10.	Aliaga, Cesar: 1 article (11/2021)

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

12/29/2021 - "Interrogation of protein expression data using the Ingenuity Pathway Analysis (IPA) bioinformatics platform indicated that 4-oxo-DHA differentially impacted six canonical pathways and the cellular functions they regulate across common molecular subtypes of breast cancer. "
11/01/2021 - "In breast cancer cell lines, 4-OXO-DHA induced PPARɣ and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) but inhibited the activity of NF-κB and suppressed PI3K and mTOR signaling. "
02/01/2015 - "The inhibitory effect was more pronounced on triple-negative basal breast cancer cell lines as compared to luminal breast cancer cell lines after 4-OXO-DHA treatment. "
02/01/2015 - "The in vitro antiproliferative effects of n-3 PUFA docosahexaenoic acid (DHA) and its metabolite, 4-OH-DHA as well as its putative metabolite 4-OXO-DHA, were tested in five triple-negative human basal breast cell lines at different stages of transformation (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT-549) and three luminal breast cancer cell lines (MCF-7, T-47D, and SK-BR-3). "

Related Drugs and Biologics

1.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
2.	Proteins (Proteins, Gene)
3.	Phenobarbital (Luminal)
4.	Docosahexaenoic Acids
5.	15-hydroxyprostaglandin dehydrogenase