PF-5190457

a ghrelin receptor inverse agonist; structure in first source

Also Known As:

2-(2-methylimidazo(2,1-b)(1,3)thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro(3.5)non-7-ylethanone; PF-05190457

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azetines
    - Azetidines: 6
      - PF-5190457: 5
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - PF-5190457: 5
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - PF-5190457: 5

Experts

1.	Akhlaghi, Fatemeh: 4 articles (01/2021 - 07/2015)
2.	Leggio, Lorenzo: 4 articles (01/2021 - 07/2015)
3.	Cobbina, Enoch: 2 articles (01/2021 - 01/2020)
4.	Lee, Mary R: 2 articles (01/2021 - 01/2020)
5.	Ghareeb, Mwlod: 2 articles (01/2020 - 07/2015)
6.	Bouhlal, Sofia: 1 article (01/2020)
7.	Dias, Alexandra A: 1 article (01/2020)
8.	Farinelli, Lisa A: 1 article (01/2020)
9.	Farokhnia, Mehdi: 1 article (01/2020)
10.	Heilig, Markus: 1 article (01/2020)

Related Diseases

1.	Alcoholism (Alcohol Abuse) 01/01/2020 - "PK/PD/behavioral findings support continued research of PF-5190457 as a potential pharmacological agent to treat alcohol use disorder." 11/01/2019 - "PF-5190457 is a selective and potent ghrelin receptor inverse agonist presently undergoing clinical trials to treat alcohol use disorder (AUD). " 01/01/2021 - "PF-5190457 is the first inverse agonist of GHS-R1a to progress to clinical development with potential to treat alcohol use disorder. " 07/01/2015 - "PF-5190457 is a ghrelin receptor inverse agonist that is currently undergoing clinical development for the treatment of alcoholism. " 01/01/2022 - "In this review we summarize and compare Baclofen, Gabapentin, Topiramate, Ondansetron, Varenicline, Aripiprazole, Quetiapine, Clozapine, Antidepressants, Lithium, Neuropeptide Y, Neuropeptide S, Corticotropin-releasing factor antagonists, Oxytocin, PF-05190457, Memantine, Ifenprodil, Samidorphan, Ondelopran, ABT-436, SSR149415, Mifepristone, Ibudilast, Citicoline, Rimonabant, Surinabant, AM4113 and Gamma-hydroxybutyrate While some have shown promising results in the treatment of alcohol use disorder, others have disappointed and should be excluded from further investigation. "
2.	Sleepiness 01/01/2021 - "This work provides an accurate, precise, and robust two-compartment model that describes the pharmacokinetics of PF-5190457 and suggests a possible link of PF-5190457 pharmacokinetics with somnolence. "

Related Drugs and Biologics

1.	Ondansetron (Zofran)
2.	Mifepristone (RU 486)
3.	Sodium Oxybate (gamma Hydroxybutyrate)
4.	Oxytocin (Pitocin)
5.	Neuropeptides
6.	Neuropeptide Y
7.	Memantine (Namenda)
8.	Lithium
9.	Cytidine Diphosphate Choline (Citicoline)
10.	Corticotropin-Releasing Hormone