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LZ-207

has antineoplastic activity; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        LZ-207: 1
  - Piperazines: 26
    - LZ-207: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        LZ-207: 1

Experts

1.	Guo, Qinglong: 1 article (01/2015)
2.	Li, Fanni: 1 article (01/2015)
3.	Li, Zhiyu: 1 article (01/2015)
4.	Lu, Na: 1 article (01/2015)
5.	Qiao, Chen: 1 article (01/2015)
6.	Sun, Jie: 1 article (01/2015)
7.	Zhao, Li: 1 article (01/2015)
8.	Zhao, Yue: 1 article (01/2015)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 01/01/2015 - "The anticancer effect of LZ-207 against HCT116 colon cancer cells and the underlying mechanism of this effect were explored in this study. " 01/01/2015 - "Specifically, LZ-207 exhibited inhibitory effects on growth and viability in several human colon cancer cell lines and induced apoptosis in HCT116 cells both in vitro and in vivo. " 01/01/2015 - "These findings elucidated some potential molecular mechanisms for preventing inflammation-driven colon cancer using the newly synthesized flavonoid LZ-207 and suggested the possibility of further developing novel therapeutic agents derived from flavonoids. " 01/01/2015 - "LZ-207, a Newly Synthesized Flavonoid, Induces Apoptosis and Suppresses Inflammation-Related Colon Cancer by Inhibiting the NF-κB Signaling Pathway."
2.	Acute Monocytic Leukemia (Acute Monoblastic Leukemia) 01/01/2015 - "LZ-207 treatment also suppressed the nuclear translocation of NF-κB and the phosphorylation of IκB and IKKα/β in a dose-dependent manner in both HCT116 cells and human acute monocytic leukemia THP-1 cells. "
3.	Inflammation (Inflammations) 01/01/2015 - "These findings elucidated some potential molecular mechanisms for preventing inflammation-driven colon cancer using the newly synthesized flavonoid LZ-207 and suggested the possibility of further developing novel therapeutic agents derived from flavonoids. " 01/01/2015 - "LZ-207, a Newly Synthesized Flavonoid, Induces Apoptosis and Suppresses Inflammation-Related Colon Cancer by Inhibiting the NF-κB Signaling Pathway."

Related Drugs and Biologics

1.	Flavonoids