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N- (2- chloro- 3- (trifluoromethyl)benzyl)- N- methyl- 5- oxopyrrolidine- 2- carboxamide

structure in first source

Also Known As:

GSK1482160

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - Pyrrolidonecarboxylic Acid: 255
        N-(2-chloro-3-(trifluoromethyl)benzyl)-N-methyl-5-oxopyrrolidine-2-carboxamide: 3
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - Pyrrolidonecarboxylic Acid: 255
        N-(2-chloro-3-(trifluoromethyl)benzyl)-N-methyl-5-oxopyrrolidine-2-carboxamide: 3
  - Cyclic Amino Acids: 3
    - Imino Acids: 11
      - Pyrrolidonecarboxylic Acid: 255
        N-(2-chloro-3-(trifluoromethyl)benzyl)-N-methyl-5-oxopyrrolidine-2-carboxamide: 3

Experts

1.	Egan, Terrance M: 1 article (05/2017)
2.	Han, Junbin: 1 article (05/2017)
3.	Jin, Hongjun: 1 article (05/2017)
4.	Liu, Chunling: 1 article (05/2017)
5.	Liu, Hui: 1 article (05/2017)
6.	Perlmutter, Joel S: 1 article (05/2017)
7.	Tu, Zhude: 1 article (05/2017)
8.	Christofi, Fievos L: 1 article (07/2014)
9.	Jacobson, Kenneth A: 1 article (07/2014)
10.	Liñán-Rico, Andromeda: 1 article (07/2014)

Related Diseases

1.	Pain (Aches) 07/01/2014 - "Drugs for pain in clinical trials include P2X(3)/P2X(2/3) (AF-219) and P2X(7) (GSK1482160) antagonists and A(1) (GW493838) or A(2A) (BVT.115959) agonists. "
2.	Multiple Sclerosis 05/01/2017 - "In the current study, we further characterized its binding profile and determined whether [C]GSK1482160 can detect changes in P2X7R expression in a rodent model of multiple sclerosis. "
3.	Ankylosing Spondylitis 10/01/2023 - "Ankylosing spondylitis PET imaging and quantifications via P2X7 receptor-targeting radioligand [18F]GSK1482160."
4.	Inflammation (Inflammations) 05/01/2017 - "GSK1482160, a P2X7R modulator with nanomolar binding affinity and high selectivity, has been successfully radiolabeled and utilized for imaging P2X7 levels in a mouse model of lipopolysaccharide-induced systemic inflammation. "
5.	Neuroinflammatory Diseases 05/01/2017 - "We conclude that [C]GSK1482160 has the potential for application in monitoring neuroinflammation."

Related Drugs and Biologics

1.	Purinergic P2X7 Receptors
2.	Lipopolysaccharides