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TV-1380

used to metabolize cocaine to treat cocaine addiction

Also Known As:

Albu-BChE

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Albumins: 31532
    - TV-1380: 5
  - Recombinant Proteins: 2754
    - Recombinant Fusion Proteins: 333
      - TV-1380: 5
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Carboxylic Ester Hydrolases: 62
        Cholinesterases: 2675
        Butyrylcholinesterase: 1150
        TV-1380: 5

Experts

1.	Deng, Jing: 2 articles (01/2022 - 11/2019)
2.	Jin, Zhenyu: 2 articles (01/2022 - 11/2019)
3.	Shang, Linyue: 2 articles (01/2022 - 11/2019)
4.	Zhan, Chang-Guo: 2 articles (01/2022 - 11/2019)
5.	Zheng, Fang: 2 articles (01/2022 - 11/2019)
6.	Gross, Aviva: 2 articles (01/2018 - 05/2015)
7.	Hallak, Hussein: 2 articles (01/2018 - 09/2016)
8.	Cohen-Barak, Orit: 2 articles (09/2016 - 05/2015)
9.	Gilgun-Sherki, Yossi: 2 articles (09/2016 - 05/2015)
10.	Chen, Xiabin: 1 article (01/2022)

Related Diseases

1.

Cocaine-Related Disorders (Cocaine Addiction)

11/21/2019 - "However, the actual therapeutic value of TV-1380 for cocaine addiction treatment is still limited by the short half-life. "
01/01/2022 - "However, the biological half-life of TV-1380 (t1/2 = 8 h in rats, associated with t1/2 = 43-77 h in humans) is not long enough for practical treatment of cocaine dependence, which requires enzyme injection for no more than once weekly. "
05/01/2015 - "Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects."
09/01/2016 - "While the apparent reduction in cocaine use may be of insufficient magnitude to justify further trials of TV-1380 in cocaine dependence, the results argue for development of improved enzymes with greater catalytic activity."
09/01/2016 - "Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence."

Related Drugs and Biologics

1.	Cocaine (Cocaine HCl)
2.	Enzymes
3.	Ethanol (Ethyl Alcohol)
4.	cocaethylene
5.	Proteins (Proteins, Gene)
6.	Butyrylcholinesterase

Related Therapies and Procedures

1.	Intramuscular Injections