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25-O-acetyl-23,24-dihydro-cucurbitacin F

antineoplastic from leaves and twigs of Quisqualis indica; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - 25-O-acetyl-23,24-dihydro-cucurbitacin F: 1

Experts

1.	Bauer, Rudolf: 1 article (04/2015)
2.	Bernhart, Eva: 1 article (04/2015)
3.	Kahl, Stefan: 1 article (04/2015)
4.	Kaltenegger, Heike: 1 article (04/2015)
5.	Kretschmer, Nadine: 1 article (04/2015)
6.	Leithner, Andreas: 1 article (04/2015)
7.	Lohberger, Birgit: 1 article (04/2015)
8.	Rinner, Beate: 1 article (04/2015)
9.	Stuendl, Nicole: 1 article (04/2015)

Related Diseases

1.

Sarcoma (Soft Tissue Sarcoma)

04/22/2015 - "25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells."
04/22/2015 - "The present study investigates the effects of 25-O-acetyl-23,24-dihydro-cucurbitacin F (1) on cell viability, cell cycle distribution, and apoptotic induction of three human sarcoma cell lines of various origins by using the CellTiter 96(®) AQueous One Solution Cell Proliferation Assay, flow cytometrical experiments, real-time RT-PCR, Western blotting, and the Caspase-Glo(®) 3/7 Assay We could show that 1 reduced cell viability in a dose-dependent manner and arrested the cells at the G2/M interface. "

Related Drugs and Biologics

1.	Caspases
2.	Solutions