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NRL972

a fluorescent-labelled bile salt, an investigational marker of hepatic biliary transporter function

Also Known As:

fluorescein lisicol

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - Fluoresceins: 2
        NRL972: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Fluoresceins: 2
        NRL972: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - Fluoresceins: 2
    - NRL972: 1

Experts

1.	Deliyska, Boriana: 1 article (07/2015)
2.	Gatchev, Emil: 1 article (07/2015)
3.	de Mey, Christian: 1 article (07/2015)

Related Diseases

1.

Renal Insufficiency (Renal Failure)

07/01/2015 - "Renal insufficiency does not impair the elimination of NRL972; instead, there is a trend of enhanced NRL972 disposition in patients with compromised renal function. "
07/01/2015 - "To investigate the pharmacokinetics (PK) of NRL972 in patients with severe (SRI: creatinine clearance (CLCr)<30 mL/min per 1.73 m2 body surface area (BSA)) and mild-to-moderate renal insufficiency (MRI: 30≤CLCr<80 mL/min) relative to matched controls (CON: CLCr≥90 mL/min). "
07/01/2015 - "Effects of renal insufficiency on the elimination of fluorescein lisicol (NRL972), an investigational marker of hepatic transporter function."

Related Drugs and Biologics

1.	NRL972
2.	Creatinine