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alanyl-alanyl-prolyl-valine

an elastase inhibitor

Also Known As:

AAPV tetrapeptide; Ala-Ala-Pro-Val

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - alanyl-alanyl-prolyl-valine: 10

Experts

1.	Costa, Susana P G: 1 article (01/2017)
2.	Gonçalves, M Sameiro T: 1 article (01/2017)
3.	Santos, Filipa C: 1 article (01/2017)
4.	Soares, Ana M S: 1 article (01/2017)
5.	Chen, Dequan: 1 article (04/2006)
6.	Deng, Youping: 1 article (04/2006)
7.	Duggan, Chris: 1 article (04/2006)
8.	Langford, Marlyn P: 1 article (04/2006)
9.	Redens, Thomas B: 1 article (04/2006)
10.	Texada, Donald E: 1 article (04/2006)

Related Diseases

1.	Hemorrhage 07/01/1995 - "The PMN elastase inhibitor, methoxysuccinyl-alanyl-alanyl-prolyl-valine-chloromethylketone, also inhibited hemorrhage in this model. " 03/01/1990 - "A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster." 03/01/1990 - "Methoxysuccinyl-alanyl-alanyl-prolyl-valine-chloromethylketone (MeOSuc-AAPV-CMK), as well as alpha 1-proteinase inhibitor (alpha 1PI) but not tosyl-lysine-chloromethylketone (tosyl-lysine-CMK), inhibited the hemorrhage caused by human PMN elastase, but the specific inhibitors of this enzyme had no effect on thermolysin-induced lung hemorrhage. "
2.	Chronic Periodontitis 02/01/1995 - "Inflamed tissue was obtained from chronic periodontitis patients, and cryostat sections were incubated with the histochemical elastase substrate MeOSuc-Ala-Ala-Pro-Val-MNA. "
3.	Reoviridae Infections 05/31/2005 - "To directly assess the role of NE in reovirus infection of U937 cells, we examined viral growth in the presence of N-Ala-Ala-Pro-Val chloromethylketone, a NE-specific inhibitor. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2017 - "Ala-Ala-Pro-Val (AAPV) is a bioactive tetrapeptide that inhibits human neutrophil elastase, an enzyme involved in skin chronic inflammatory diseases like psoriasis. "
5.	Pneumonia (Pneumonitis) 07/01/1995 - "Patients with CF had active pulmonary inflammation; neutrophils were abundant in the bronchoalveolar lavage fluid of the CF group and correlated with elastase activity measured with methoxysuccinyl Ala-Ala-Pro-Val paranitroanilide (r = 0.61, p < 0.05). "

Related Drugs and Biologics

1.	Pancreatic Elastase (Elastase)
2.	Leukocyte Elastase (Neutrophil Elastase)
3.	Enzymes
4.	beta-Lactams
5.	Guanidine (Guanidine Nitrate)
6.	Trypsin
7.	Thermolysin
8.	Lysine (L-Lysine)
9.	Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
10.	Dactinomycin (Actinomycin)