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17- (6- (3,4- dimethoxycinnamamido)hexylamino)- 17- demethoxy- geldanamycin

inhibits prostate cancer cells; structure in first source

Also Known As:

17-DMCHAG

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Lactams: 2198
    - Macrocyclic Lactams: 28
      - 17-(6-(3,4-dimethoxycinnamamido)hexylamino)-17-demethoxy-geldanamycin: 1
- Quinones: 434
  - Benzoquinones: 25
    - 17-(6-(3,4-dimethoxycinnamamido)hexylamino)-17-demethoxy-geldanamycin: 1
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Macrocyclic Lactams: 28
    - 17-(6-(3,4-dimethoxycinnamamido)hexylamino)-17-demethoxy-geldanamycin: 1

Experts

1.	Li, Zhenyu: 1 article (06/2015)
2.	Lin, Zhiyuan: 1 article (06/2015)
3.	Lu, Chunhua: 1 article (06/2015)
4.	Peng, Ruixian: 1 article (06/2015)
5.	Shen, Yuemao: 1 article (06/2015)
6.	Shi, Guowei: 1 article (06/2015)
7.	Wang, Jifeng: 1 article (06/2015)
8.	Wang, Meifang: 1 article (06/2015)
9.	Wang, Yang: 1 article (06/2015)
10.	Zhao, Baobing: 1 article (06/2015)

Related Diseases

1.

Prostatic Neoplasms (Prostate Cancer)

06/28/2015 - "Thus, 17-DMCHAG is a potential treatment for prostate cancer."
06/28/2015 - "Treatment of cells with 17-DMCHAG (17-(6-(3,4-dimethoxycinnamamido)hexylamino)-17-demethoxy-geldanamycin) dose-dependently suppressed the proliferation, reduced colony formation and induced apoptosis of human prostate cancer cell lines. "
06/28/2015 - "17-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation."
06/28/2015 - "17-DMCHAG exhibits anti-invasive and anti-migratory activities in prostate cancer cells through down-regulating of transcription factors Zeb1, Snail1, Slug, and mesenchymal marker Vimentin, while up-regulating the epithelial marker of E-cadherin. "

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	Vimentin
3.	Transcription Factors (Transcription Factor)
4.	Survivin
5.	geldanamycin