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1,2- dioleoyl- sn- glycero- 3- phosphoethanolamine- N- arachidonoyl
Also Known As:
20:4-NAPE
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Lipids: 114793
Membrane Lipids: 1591
Phospholipids: 11903
Glycerophosphates: 118
Phosphatidic Acids: 358
Glycerophospholipids: 689
Phosphatidylethanolamines: 167
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-arachidonoyl: 2
Experts
1.
Adamek, Pavel
: 1 article (01/2018)
2.
Mrozkova, Petra
: 1 article (01/2018)
3.
Nagy, Istvan
: 1 article (01/2018)
4.
Nerandzic, Vladimir
: 1 article (01/2018)
5.
Palecek, Jiri
: 1 article (01/2018)
6.
Spicarova, Diana
: 1 article (01/2018)
Related Diseases
1.
Inflammation (Inflammations)
01/01/2018 - "
While 20:4-NAPE treatment inhibited the excitatory synaptic transmission in both naive and inflammatory conditions, peripheral inflammation altered the underlying mechanisms.
"
01/01/2023 - "
Our results show that 20:4-NAPE application has a significant modulatory effect on spinal cord nociceptive signaling that is mediated by both TRPV1 and CB1 presynaptic receptors, whereas peripheral inflammation changes the underlying mechanism.
"
01/01/2018 - "
Our data indicate that 20:4-NAPE application induced mainly CB1 receptor-mediated inhibitory effects in naive animals while TRPV1-mediated mechanisms were also involved after inflammation.
"
01/01/2023 - "
The switch between TRPV1 and CB1 receptor activation by the AEA precursor 20:4-NAPE during inflammation may play an important role in nociceptive processing, hence the development of pathological pain.
"
01/01/2018 - "
After inflammation, 20:4-NAPE increased sEPSCs frequency in the presence of PF514273 and this increase was blocked by SB366791.
"
2.
Pain (Aches)
01/01/2023 - "
The switch between TRPV1 and CB1 receptor activation by the AEA precursor 20:4-NAPE during inflammation may play an important role in nociceptive processing, hence the development of pathological pain.
"
Related Drugs and Biologics
1.
CB1 Cannabinoid Receptor (CB1 Receptor)
2.
Presynaptic Receptors
3.
2- (2- chlorophenyl)- 3- (4- chlorophenyl)- 7- (2,2- difluoropropyl)- 6,7- dihydro- 2H- pyrazolo(3,4- f)(1,4)oxazepin- 8(5H)- one
4.
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