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N- (5- ((2- (2- (hexadecyloxy)ethoxy)- 2- oxido- 1,4,2- dioxaphosphinan- 5- yl)methyl)- 4- oxo- 4,5- dihydro- 1,3,5- triazin- 2- yl)docosanamide

has antiviral activity; structure in first source

Also Known As:

HPMP-5-azaC

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Cytosine: 1880
        N-(5-((2-(2-(hexadecyloxy)ethoxy)-2-oxido-1,4,2-dioxaphosphinan-5-yl)methyl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)docosanamide: 1
Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - N-(5-((2-(2-(hexadecyloxy)ethoxy)-2-oxido-1,4,2-dioxaphosphinan-5-yl)methyl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)docosanamide: 1

Experts

1.	Andrei, Graciela: 1 article (10/2008)
2.	De Clercq, Erik: 1 article (10/2008)
3.	Holý, Antonín: 1 article (10/2008)
4.	Krecmerová, Marcela: 1 article (10/2008)
5.	Naesens, Lieve: 1 article (10/2008)
6.	Neyts, Johan: 1 article (10/2008)
7.	Snoeck, Robert: 1 article (10/2008)
8.	Votruba, Ivan: 1 article (10/2008)

Related Diseases

1.	Non-Hodgkin Lymphoma (Lymphosarcoma) 10/15/2008 - "By comparing the metabolism in mouse lymphosarcoma S49-wild type (S49-WT) and mutant cells deficient for dCMP deaminase, we identified the mono- and diphosphate metabolites generated from HPMP-5-azaC and its deaminated product HPMP-5-azaU. "
2.	Carcinoma (Carcinomatosis) 10/15/2008 - "In human lung carcinoma A549 cells, the relative formation of the deaminated metabolites was only 6%, implying that deamination plays a minor role in the overall metabolism of HPMP-5-azaC. "
3.	Adenoviridae Infections (Adenovirus Infections) 10/15/2008 - "Herpes-, pox- or adenovirus infection had no marked influence on the metabolism of HPMP-5-azaC. "

Related Drugs and Biologics

1.	Diphosphates (Pyrophosphates)
2.	DCMP Deaminase (Deoxycytidylate Deaminase)