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dual orexin receptor antagonist 12

DORA - dual orexin receptor antagonist; an antagonist of both orexin 1 and oxexin 2 receptors

Also Known As:

DORA-12

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - dual orexin receptor antagonist 12: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - dual orexin receptor antagonist 12: 2

Experts

1.	Coleman, Paul J: 1 article (01/2016)
2.	Gotter, Anthony L: 1 article (01/2016)
3.	Kuduk, Scott D: 1 article (01/2016)
4.	Liang, Hongyu A: 1 article (01/2016)
5.	McDonald, Terrence: 1 article (01/2016)
6.	Renger, John J: 1 article (01/2016)
7.	Sanoja, Raul: 1 article (01/2016)
8.	Smith, Karen M: 1 article (01/2016)
9.	Winrow, Christopher J: 1 article (01/2016)

Related Diseases

1.	Tauopathies 01/01/2023 - "We observed a significant effect of DORA-12 on objective measures of RBD, thereby encouraging future exploration of DORA effects on sleep-mediated cognition and RBD treatment.SIGNIFICANCE STATEMENT The specific effect of tauopathy on sleep macroarchitecture and microarchitecture throughout aging remains unknown. "
2.	Pain (Aches) 01/01/2016 - "Pharmacological treatment with the potent, selective and structurally distinct dual orexin receptor antagonists (ORAs) DORA-12 and DORA-2 significantly reduced pain responses during both phases I and II of the mouse formalin pain model and significantly reversed hyperalgesia in the rat complete Freund's adjuvant pain model, respectively. "
3.	Hyperalgesia 01/01/2016 - "Pharmacological treatment with the potent, selective and structurally distinct dual orexin receptor antagonists (ORAs) DORA-12 and DORA-2 significantly reduced pain responses during both phases I and II of the mouse formalin pain model and significantly reversed hyperalgesia in the rat complete Freund's adjuvant pain model, respectively. "

Related Drugs and Biologics

1.	Freund's Adjuvant
2.	Formaldehyde (Formol)
3.	Orexin Receptor Antagonists