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5- (2- (4- bromophenyl)vinyl)- 1,3- benzenediol

inhibits both Sirt1 and Sirt3; structure in first source

Also Known As:

4'-bromo-resveratrol

Networked: 3 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Resorcinols: 4
        5-(2-(4-bromophenyl)vinyl)-1,3-benzenediol: 3
        Benzylidene Compounds: 10
        Stilbenes: 657
        5-(2-(4-bromophenyl)vinyl)-1,3-benzenediol: 3

Experts

1.	Ahmad, Nihal: 2 articles (01/2022 - 10/2019)
2.	Singh, Chandra K: 2 articles (01/2022 - 10/2019)
3.	Chhabra, Gagan: 1 article (01/2022)
4.	Guzmán-Pérez, Glorimar: 1 article (01/2022)
5.	Iczkowski, Kenneth A: 1 article (01/2022)
6.	Ndiaye, Mary A: 1 article (01/2022)
7.	Chen, Chih-Yi: 1 article (12/2021)
8.	Chen, Chun-Lin: 1 article (12/2021)
9.	Lin, Ming-Wei: 1 article (12/2021)
10.	Ma, Yi-Shih: 1 article (12/2021)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "In this study, we determined the antimelanoma efficacy of 4'-bromo-resveratrol (4'-BR), which is a small-molecule dual inhibitor of SIRT1 and SIRT3, in a BrafV600E/PtenNULL mouse model that recapitulates human disease, including metastases. "
2.	Melanoma (Melanoma, Malignant) 10/01/2019 - "4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming." 10/01/2019 - "In this study, we determined the antiproliferative efficacy of a newly identified dual small molecule inhibitor of SIRT1 and SIRT3, 4'-bromo-resveratrol (4'-BR), in human melanoma cell lines (G361, SK-MEL-28, and SK-MEL-2). "
3.	Stomach Neoplasms (Stomach Cancer) 12/22/2021 - "We evaluated the stemness inhibition ability of the SIRT3 inhibitor 4'-bromo-resveratrol (4-BR), an analog of resveratrol in human gastric cancer cells. "

Related Drugs and Biologics

1.	Sirtuin 3
2.	Sirtuin 1
3.	Resveratrol