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12-hydroxynevirapine sulfate

a metabolite of nevirapine; structure in first source

Also Known As:

12-OH-NVP sulfate; 12-OH-nevirapine sulfate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Nevirapine: 887
      - 12-hydroxynevirapine sulfate: 2

Experts

1.	Sharma, Amy M: 2 articles (05/2013 - 03/2013)
2.	Novalen, Maria: 1 article (05/2013)
3.	Tanino, Tadatoshi: 1 article (05/2013)
4.	Uetrecht, Jack P: 1 article (05/2013)
5.	Klarskov, Klaus: 1 article (03/2013)
6.	Uetrecht, Jack: 1 article (03/2013)

Related Diseases

1.

Exanthema (Rash)

03/18/2013 - "These data provide strong evidence that covalent binding of NVP in the skin is due to 12-OH-NVP sulfate, which is likely responsible for NVP-induced skin rash. "
05/20/2013 - "Salicylamide (SA), which depletes 3'-phosphoadenosine-5'-phosphosulfate (PAPS) in the liver, significantly decreased 12-OH-NVP sulfate in the blood, but it did not prevent covalent binding in the skin or the rash. "
05/20/2013 - "12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash."

Related Drugs and Biologics

1.	Nevirapine (Viramune)
2.	salicylamide