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CXC137

has neuroprotective activity; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrazines: 150
    - CXC137: 2
  - Piperazines: 26
    - CXC137: 2

Experts

1.	Chen, Yong: 1 article (05/2015)
2.	Cheng, Ye: 1 article (05/2015)
3.	Gao, Hai-Jun: 1 article (05/2015)
4.	Huang, Hai-Yan: 1 article (05/2015)
5.	Huang, Zhuo-Yan: 1 article (05/2015)
6.	Lei, Ting: 1 article (05/2015)
7.	Li, Pei-Wen: 1 article (05/2015)
8.	Liu, Peng-Fei: 1 article (05/2015)
9.	Mu, Qing-Chun: 1 article (05/2015)
10.	Yu, Feng-Bo: 1 article (05/2015)

Related Diseases

1.	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 02/01/2014 - "In a vascular dementia rat model established by bilateral common carotid arteries occlusion, treatment with CXC137 from 2 to 35 day of post-operation significantly improves the motor performance, spatial learning and memory capability of rats in both the prehensile traction test and Morris water maze test, an effect that was companied by reductions of the animal glutamic acid levels and the degree of brain mitochondrial swelling. " 02/01/2014 - "A tetramethylpyrazine piperazine derivate CXC137 prevents cell injury in SH-SY5Y cells and improves memory dysfunction of rats with vascular Dementia." 02/01/2014 - "We investigated the effects of CXC137, a tetramethylpyrazine piperazine derivate, on cell damage induced by N-methyl-D-aspartate (NMDA) in human derived neuroblastoma cells (SH-SY5Y) and its effect on memory dysfunction of rats with vascular dementia. "
2.	Neuroblastoma 02/01/2014 - "We investigated the effects of CXC137, a tetramethylpyrazine piperazine derivate, on cell damage induced by N-methyl-D-aspartate (NMDA) in human derived neuroblastoma cells (SH-SY5Y) and its effect on memory dysfunction of rats with vascular dementia. "
3.	Dementia (Dementias) 02/01/2014 - "These results suggest that CXC137 can improve the memory dysfunction in dementia and thus has important therapeutic potential for the treatment of dementia. "
4.	Brain Ischemia (Cerebral Ischemia) 05/01/2015 - "The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, CXC137 and CXC195 after cerebral ischemia were better than ligustrazine. "

Related Drugs and Biologics

1.	tetramethylpyrazine
2.	Glutamic Acid (Glutamate)
3.	N-Methylaspartate (NMDA)
4.	Piperazine
5.	CXC 195
6.	Aligeron (AS 2)

Related Therapies and Procedures

1.	Traction