HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

S- 4- (4- ethyl- 7- isopropyl- 2,5,8,12- tetraoxo- 9- oxa- 3,6,13,18- tetraazabicyclo(13,2,1)octadec- 1- en- 10- yl)but- 3- enyl octanethioate

has antineoplastic activity

Also Known As:

PQJS380

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - S-4-(4-ethyl-7-isopropyl-2,5,8,12-tetraoxo-9-oxa-3,6,13,18-tetraazabicyclo(13,2,1)octadec-1-en-10-yl)but-3-enyl octanethioate: 1
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - S-4-(4-ethyl-7-isopropyl-2,5,8,12-tetraoxo-9-oxa-3,6,13,18-tetraazabicyclo(13,2,1)octadec-1-en-10-yl)but-3-enyl octanethioate: 1

Experts

1.	Chen, Chun: 1 article (01/2014)
2.	Chen, Dong: 1 article (01/2014)
3.	Chen, Li: 1 article (01/2014)
4.	Jiang, Sheng: 1 article (01/2014)
5.	Pan, Jingxuan: 1 article (01/2014)
6.	Xue, Hongman: 1 article (01/2014)
7.	Yao, Yiwu: 1 article (01/2014)
8.	Zhu, Xiaohui: 1 article (01/2014)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/2014 - "PQJS380: a novel lead compound to induce apoptosis in acute lymphoblastic leukemia cells."
2.	Leukemia 01/01/2014 - "The median IC 50 value for leukemia blast cells from 17 patients with ALL was 52 nM. PQJS380 induced G 1-phase arrest in REH cells, and S-phase in NALM-6 cells, respectively. " 01/01/2014 - "In the course of seeking novel agents against ALL, we screened a library of small molecules and identified that PQJS380, a S-(E)-4-([7S,10S]-4-ethyl-7-isopropyl-2,5,8,12-tetraoxo-9-oxa-3,6,13,18-tetraaza-bicycle[13,2,1] octadec-1-en-10-yl)but-3-enyl octanethioate, showed potent anti-leukemia activity. "