vacquinol-1

01/01/2021 - "The mechanism of action of the cationic amphiphilic drug Vacquinol-1 (Vacq1)-induced cytotoxicity was investigated using cell biology, biochemistry, functional experiments, chemical biology, unbiased antibody-based post-translation modification profiling, and mass spectrometry-based chemical proteomic analysis on patient-derived glioblastoma cells. "
01/01/2021 - "Glioblastoma cytotoxicity conferred through dual disruption of endolysosomal homeostasis by Vacquinol-1."
02/02/2018 - "Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1."
08/01/2014 - "In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells. "
05/23/2017 - "Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP."

10/01/2014 - "Vacquinol-1 displays excellent in vivo pharmacokinetics and brain exposure, attenuates disease progression, and prolongs survival in a GBM animal model. "