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ORM-12741

an alpha-2C adrenoceptor antagonist

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - ORM-12741: 4
    - Quinolizines: 1
      - Quinolizidines: 13
        ORM-12741: 4

Experts

1.	Rouru, Juha: 3 articles (12/2020 - 05/2014)
2.	Rinne, Juha O: 2 articles (12/2020 - 01/2017)
3.	Scheinin, Mika: 2 articles (12/2020 - 01/2017)
4.	Shahid, Mohammed: 2 articles (12/2020 - 01/2017)
5.	Hakulinen, Pasi: 2 articles (01/2017 - 05/2014)
6.	Arponen, Eveliina: 1 article (12/2020)
7.	Kuokkanen, Katja: 1 article (12/2020)
8.	Marjamäki, Päivi: 1 article (12/2020)
9.	Sallinen, Jukka: 1 article (12/2020)
10.	Solin, Olof: 1 article (12/2020)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2017 - "This trial evaluated the safety and efficacy of ORM-12741 in patients with Alzheimer's disease (AD). " 01/01/2017 - "Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease." 01/01/2017 - "ORM-13070 is a useful positron emission tomography ligand, ORM-10921 has demonstrated antipsychotic, antidepressant, and pro-cognitive actions in animals, while ORM-12741 is in clinical development for the treatment of cognitive dysfunction and neuropsychiatric symptoms in Alzheimer's disease. "
2.	Systemic Scleroderma (Systemic Sclerosis) 05/01/2014 - "A double-blind, randomized, placebo-controlled crossover trial of the α2C-adrenoceptor antagonist ORM-12741 for prevention of cold-induced vasospasm in patients with systemic sclerosis."
3.	Cognitive Dysfunction 01/01/2017 - "ORM-13070 is a useful positron emission tomography ligand, ORM-10921 has demonstrated antipsychotic, antidepressant, and pro-cognitive actions in animals, while ORM-12741 is in clinical development for the treatment of cognitive dysfunction and neuropsychiatric symptoms in Alzheimer's disease. "
4.	Brain Diseases (Brain Disorder) 12/09/2020 - "Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain function, both in healthy humans and in patients with various brain disorders. "

Related Drugs and Biologics

1.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
2.	Antipsychotic Agents (Antipsychotics)
3.	Ligands
4.	Antidepressive Agents (Antidepressants)
5.	ORM-10921