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CBS-3595

inhibits both p38 MAP kinase and phosphodiesterase 4; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - CBS-3595: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - CBS-3595: 1
  - Pyridines: 88
    - Aminopyridines: 77
      - CBS-3595: 1

Experts

1.	Campos, Maria M: 1 article (03/2014)
2.	Koch, Diana A: 1 article (03/2014)
3.	Laufer, Stefan: 1 article (03/2014)
4.	Leite, Carlos E: 1 article (03/2014)
5.	Morrone, Fernanda B: 1 article (03/2014)
6.	Nicoletti, Natália F: 1 article (03/2014)
7.	Silva, Rodrigo B M: 1 article (03/2014)
8.	de Souza, Alessandra H: 1 article (03/2014)

Related Diseases

1.

Arthritis (Polyarthritis)

03/01/2014 - "In the present study we compared the effects of the selective p38 inhibitor ML3403 and the dual p38-PDE4 inhibitor CBS-3595, on inflammatory and nociceptive parameters in a model of polyarthritis in rats. "
03/01/2014 - "Repeated CBS-3595 (3 mg/kg) or ML3403 (10 mg/kg) administration produced significant anti-inflammatory actions in the chronic arthritis model induced by CFA. "
03/01/2014 - "Efficacy and gastrointestinal tolerability of ML3403, a selective inhibitor of p38 MAP kinase and CBS-3595, a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 in CFA-induced arthritis in rats."

Related Drugs and Biologics

1.	(4- (5- (4- fluorophenyl)- 2- methylsulfanyl- 3H- imidazol- 4- yl)pyridin- 2- yl)- (1- phenylethyl)amine
2.	Type 4 Cyclic Nucleotide Phosphodiesterases
3.	p38 Mitogen-Activated Protein Kinases