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Esophageal Achalasia (Megaesophagus) Summary

Description: A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

Also Known As: Megaesophagus; Cardiospasm; Achalasia; Achalasias; Achalasias, Esophageal Show All >>

Networked: 1407 relevant articles (137 outcomes, 168 trials/studies) for this Disease

Key Drugs and Agents for Esophageal Achalasia

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Botulinum Toxins (Botulinum Toxin) : 32 outcomes 25 studies in 183 results : IBA
  2. onabotulinumtoxinA (Botox) : 7 outcomes 5 studies in 30 results : FDA 1
  3. Nifedipine (Adalat) : 6 outcomes 12 studies in 35 results : FDA 25 Generic
  4. Barium : 5 outcomes 28 studies in 123 results : IBA
  5. Cosmetics : 2 outcomes in 6 results : IBA
  6. Colloids (Colloid) : 1 outcome 3 studies in 4 results : IBA
  7. Antibodies : 1 outcome 1 study in 17 results : IBA
  8. Nitric Oxide (Nitrogen Monoxide) : 1 outcome 1 study in 11 results : FDA 1
  9. Calcium Channel Blockers (Blockers, Calcium Channel) : 1 outcome 1 study in 8 results : IBA
  10. Calcium : 1 outcome in 8 results : IBA
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Diseases Related to Esophageal Achalasia

  1. Deglutition Disorders (Dysphagia)
  2. Gastroesophageal Reflux (GERD)
  3. Spasm (Spasms)
  4. Diffuse Esophageal Spasm (Esophageal Spasm)
  5. Heartburn (Pyrosis)
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Key Therapies for Esophageal Achalasia

Efficacy Chart >>
  1. Fundoplication : 39 outcomes 33 studies in 273 results
  2. Balloon Dilation : 10 outcomes 6 studies in 66 results
  3. Injections : 7 outcomes 4 studies in 38 results
  4. Stents : 6 outcomes 3 studies in 25 results
  5. Esophagectomy : 5 outcomes 4 studies in 66 results
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