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Blast Crisis (Blast Phase) Summary

Description: An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.

Also Known As: Blast Phase; Blast Crises; Blast Phases; Crises, Blast; Crisis, Blast Show All >>

Networked: 1213 relevant articles (110 outcomes, 116 trials/studies) for this Disease

Key Drugs and Agents for Blast Crisis

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. imatinib (Gleevec) : 39 outcomes 28 studies in 285 results : FDA 3
  2. dasatinib (BMS 354825) : 8 outcomes 7 studies in 47 results : FDA 2
  3. Cytarabine (Cytosar-U) : 7 outcomes 12 studies in 61 results : FDA 13 Generic
  4. Interferon-alpha (Interferon Alfa) : 5 outcomes 2 studies in 16 results : FDA 2
  5. Hydroxyurea (Hydrea) : 5 outcomes 1 study in 26 results : FDA 6 Generic
  6. Protein-Tyrosine Kinases (Tyrosine Kinase) : 5 outcomes in 53 results : IBA
  7. Vincristine (Oncovin) : 5 outcomes in 31 results : FDA 17 Generic
  8. Busulfan (Busulfex) : 4 outcomes 2 studies in 20 results : FDA 2
  9. Prednisone (Sone) : 4 outcomes 2 studies in 14 results : FDA 119 Generic
  10. 4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib) : 3 outcomes 4 studies in 23 results : FDA 1
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Diseases Related to Blast Crisis

  1. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
  2. Leukemia
  3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
  4. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
  5. Philadelphia Chromosome
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Key Therapies for Blast Crisis

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 16 outcomes 2 studies in 79 results
  2. Transplants (Transplant) : 5 outcomes 2 studies in 38 results
  3. Transplantation (Transplant Recipients) : 4 outcomes 1 study in 34 results
  4. Bone Marrow Transplantation (Transplantation, Bone Marrow) : 4 outcomes 1 study in 30 results
  5. Stem Cell Transplantation : 3 outcomes in 22 results
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