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Non-Steroidal Anti-Inflammatory Agents (NSAIDs) Summary

Description: Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)

Also Known As: NSAIDs; Anti-Inflammatory Agents, Non-Steroidal; Anti Inflammatory Agents, Nonsteroidal; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal Show All >>

Networked: 6913 relevant articles (621 outcomes, 1089 trials/studies) for this Bio-Agent

Key Diseases for which Non-Steroidal Anti-Inflammatory Agents is Relevant

  1. Pain (Aches) : 212 outcomes 142 studies in 1245 results
  2. Osteoarthritis : 52 outcomes 86 studies in 391 results
  3. Inflammation : 50 outcomes 51 studies in 561 results
  4. Neoplasms (Cancer) : 41 outcomes 99 studies in 519 results
  5. Rheumatoid Arthritis : 31 outcomes 67 studies in 324 results
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Drugs Related to Non-Steroidal Anti-Inflammatory Agents

  1. Aspirin (Acetylsalicylic Acid)
  2. Acetaminophen (Paracetamol)
  3. Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
  4. Opioid Analgesics (Opioids)
  5. Analgesics (Analgesic Drugs)
  6. celecoxib (Celebrex)
  7. Ibuprofen (Motrin)
  8. Misoprostol (Cytotec)
  9. Naproxen (Naprosyn)
  10. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
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Therapies Related to Non-Steroidal Anti-Inflammatory Agents

  1. Chemoprevention
  2. Analgesia
  3. Injections
  4. Oral Surgery (Maxillofacial Surgery)
  5. Aftercare (After-Treatment)
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