Abstract | BACKGROUND & AIMS: We sought to assess the association between intra-abdominal visceral adipose tissue (IA-VAT) and response to 3 different biologic drugs in patients with inflammatory bowel disease (IBD) and to investigate its effects on inflammatory cytokine expression, pharmacokinetics, and intestinal microbiota. METHODS: RESULTS: A total of 141 patients with IBD and 51 healthy controls were included. No differences in body composition parameters were seen between the IBD and healthy control cohorts. Patients with higher IA-VAT% were less likely to achieve corticosteroid-free deep remission (P < .001) or endoscopic remission (P = .02) vs those with lower IA-VAT%. Furthermore, nonresponders with high IA-VAT% had significantly higher serum interleukin-6 and tumor necrosis factor at baseline compared with responders and patients with low IA-VAT%. Drug pharmacokinetic properties and microbiota diversity were similar when comparing high and low IA-VAT% groups. CONCLUSIONS: Higher IA-VAT% was independently associated with worse outcomes. This association could be driven at least partially by discrete differences in inflammatory cytokine expression.
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Authors | Andres J Yarur, Alexandra Bruss, Andrea Moosreiner, Poonam Beniwal-Patel, Lizbeth Nunez, Brandon Berens, Jean F Colombel, Stephan R Targan, Caroline Fox, Gil Y Melmed, Maria T Abreu, Parakkal Deepak |
Journal | Gastroenterology
(Gastroenterology)
Vol. 165
Issue 4
Pg. 963-975.e5
(10 2023)
ISSN: 1528-0012 [Electronic] United States |
PMID | 37499955
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Tumor Necrosis Factor-alpha
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Topics |
- Humans
- Crohn Disease
(diagnosis, drug therapy, pathology)
- Colitis, Ulcerative
(diagnosis, drug therapy, pathology)
- Intra-Abdominal Fat
(diagnostic imaging, pathology)
- Inflammatory Bowel Diseases
(pathology)
- Tumor Necrosis Factor-alpha
- Biological Therapy
- Remission Induction
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