A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement.

Abstract

We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. An adrenal biopsy revealed the presence of a DLBCL, with triple expression of bcl2, bcl6, C-MYC(+70%). Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. The selection of the appropriate treatment modality can lead to profound response and improve patient's outcome.

• Authors: Labrini Papanastasiou, Nikitas Skarakis, Maria Vardaka, Anastasia Dimitriadi, Pinelopi Lampropoulou, Anastasia Perpinia, Eleftherios Vidalakis, Theodosia Choreftaki, Theodoros Marinakis, Theodora Kounadi, Ioannis-Anastasios Vatalas, Eurydiki Michalis
• Journal: Leukemia research reports (Leuk Res Rep) Vol. 17 Pg. 100318 ( 2022) ISSN: 2213-0489 [Print] England
• PMID: 35539018 (Publication Type: Case Reports)
• Copyright: © 2022 The Authors. Published by Elsevier Ltd.