Abstract |
Copper (Cu) complexes of a number of compounds have increased anti-inflammatory efficacy over the native compound. In the present study, Cu and acetylsalicylic acid (ASA) were administered to rabbits over a one week period. At the end of this time, ocular inflammation was induced by intravitreal injection of endotoxin. ASA caused a slight reduction in the inflammatory response at 24 hours, but this response was not further decreased when Cu was added to the treatment regimen. However, there was a gradual and significant increase in antioxidant activity in the plasma of animals in the combined treatment group which could not be accounted for by a Cu-ASA complex, an increase in the concentration of known plasma protein antioxidants ( ceruloplasmin and transferrin) or an increase in superoxide dismutase activity. The compound(s) responsible for this increased activity has a molecular weight greater than 10,000 Da. A large increase in plasma antioxidant activity may have a protective effect in other models of inflammation and provide a mechanism for the proven increase in anti-inflammatory efficacy of Cu-chelates of many compounds.
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Authors | M C McGahan |
Journal | Agents and actions
(Agents Actions)
Vol. 31
Issue 1-2
Pg. 59-64
(Aug 1990)
ISSN: 0065-4299 [Print] Switzerland |
PMID | 2285023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Endotoxins
- Transferrin
- Copper
- Superoxide Dismutase
- Ceruloplasmin
- Aspirin
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Aqueous Humor
(enzymology, metabolism)
- Aspirin
(pharmacology)
- Ceruloplasmin
(metabolism)
- Copper
(pharmacology)
- Endotoxins
(toxicity)
- Eye Diseases
(blood, chemically induced)
- Inflammation
(blood, chemically induced)
- Lipid Peroxidation
(drug effects)
- Molecular Weight
- Oxidation-Reduction
- Rabbits
- Superoxide Dismutase
(metabolism)
- Transferrin
(metabolism)
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