[Progress in research on mechanisms of anti-rheumatoid arthritis of triptolide].

Abstract

Extracts of Tripterygium wilfordii are effective in traditional Chinese medicine for treatment of rheumatoid arthritis (RA). Triptolide, a diterpenoid triepoxide purified from TWHF, has been identified as the major component of TWHF and might account for its therapeutic effects. To make for the clinical reasonable application and further development of triptolide, in this review was introduced the recent ten-years progress in mechanisms of anti-RA of it, including immunosuppression, anti-inflammation, inducing cell apoptosis, inhibiting vascular proliferation, protecting article cartilage and gene regulation. Triptolide is a potent immunosuppressant.

• Authors: Chun-Fang Liu, Na Lin
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 31 Issue 19 Pg. 1575-9 (Oct 2006) ISSN: 1001-5302 [Print] China
• PMID: 17165577 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cytokines
• Diterpenes
• Epoxy Compounds
• Immunosuppressive Agents
• NF-kappa B
• Phenanthrenes
• triptolide
• Dinoprostone

Topics

• Animals
• Apoptosis (drug effects)
• Arthritis, Rheumatoid (metabolism, pathology)
• Cell Proliferation (drug effects)
• Cytokines (metabolism)
• Dinoprostone (metabolism)
• Diterpenes (isolation & purification, pharmacology)
• Epoxy Compounds (isolation & purification, pharmacology)
• Humans
• Immunosuppressive Agents (pharmacology)
• NF-kappa B (metabolism)
• Neovascularization, Pathologic
• Phenanthrenes (isolation & purification, pharmacology)
• Plants, Medicinal (chemistry)
• T-Lymphocytes (pathology)
• Tripterygium (chemistry)